Past Speakers

Christopher J. Westlake, Ph.D.

Head, Membrane Trafficking and Signaling Section, 
Laboratory of Cell and Development Signaling

Wednesday, December 18, 2024 | 12:00 PM (EST)

Remodeling membranes during organelle biogenesis

Eugene Valkov, D.Phil.

Head, Messenger RNA Regulation and Decay Section, 
RNA Biology Laboratory

Wednesday, December 11, 2024 | 12:00 PM (EST) | IN PERSON ONLY

Molecular Mechanisms of mRNA Decay

Ira O. Daar, Ph.D.

Developmental Signal Transduction Section
Cancer and Developmental Biology Laboratory 

Wednesday, December 4, 2024 | 12:00 PM (EST)

Those Ephin’ Ephrins Control Cell Shape In Vivo, but the Dvl is in the Details?

Susan M. Lea D.Phil., F.Med.Sci., F.R.S.

Chief Center for Structural Biology
Center for Cancer Research National Cancer Institute

Wednesday, November 20, 2024 | 12:00 PM (EST)

Moving things across membranes - structural insights into proton-driven systems

Joseph J. Barchi Jr., Ph.D.

Structural Glycoconjugate Chemistry and NMR Section
Chemical Biology Laboratory Center for Cancer Research

Wednesday, November 13, 2024 | 12:00 PM (EST)

Rational Design of Mucin Glycopeptides as Tumor Immunotherapeutic Agents

Jairaj K. Acharya, MBBS, Ph.D.

Senior Investigator Cancer and Developmental Biology Laboratory
Head, Sphingolipid and Phospholipid Signaling Section

Wednesday, November 6, 2024 | 12:00 PM (EST)

Sphingolipids - 140 years and on, still enigmatic

Jeffrey Lifson, M.D.

Director, AIDS and Cancer Virus Program

Wednesday, October 30, 2024 | 12:00 PM (EST)

Adventures in Simian Cellular Engineering

Shuo Gu, Ph.D.

Head, RNA Mediated Gene Regulation Section
RNA Biology Laboratory

Wednesday, October 16, 2024 | 12:00 PM (EST)

Harnessing Mechanistic Insights into microRNA Function for Cancer Therapy

Denise Whitby, Ph.D.

Principal Investigator, Viral Oncology Section 
AIDS and Cancer Virus Program

Wednesday, October 2, 2024 | 12:00 PM (EST)

Sequence Variation of Kaposi’s Sarcoma-associated Herpesvirus in the Context of the Current HIV Epidemic

Jordan L. Meier, Ph.D.

Head, Epigenetics and Metabolism Section
Chemical Biology Laboratory

In Person Only | Wednesday, September 25, 2024 | 12:00 PM (EST)

Next-Generation Histone Acetyltransferase Inhibitors

Brad St. Croix, Ph.D.

Senior Scientist Mouse Cancer Genetics Program    
Head, Tumor Angiogenesis Unit

Wednesday, June 26, 2024 | 12:00 PM (EST)

Engineering antibody-drug conjugates with enhanced cancer eradicating capability

Michael Aregger, Ph.D.

Stadtman Investigator Molecular Targets Program    
Head, Functional Genomics Section

Wednesday, June 12, 2024 | 12:00 PM (EST)

Interrogating Genetic Interactions & Regulators of Metabolic Plasticity in Cancer Cells

Barbara K. Felber, Ph.D.

Senior Investigator Vaccine Branch    
Head, Human Retrovirus Pathogenesis Section

Wednesday, May 29, 2024 | 12:00 PM (EST)

Nanoparticles, Biomarkers and Vaccines

Deborah K. Morrison, Ph.D.

Chief Laboratory of Cell and Developmental Signaling    
Head, Cellular Growth Mechanisms Section

Wednesday, May 15, 2024 | 12:00 PM (EST)

Understanding RAF Kinase Regulation: The Details DO Matter!

David A. Wink Jr., Ph.D.

Deputy Chief Cancer Innovation Laboratory    
Head, Molecular Mechanisms Section

Wednesday, May 8, 2024 | 12:00 PM (EST)

NOS2 and COX2 Spatial Orientation with T-effector cells drive metastasis, cancer stemness and immunosuppression in ER- breast cancer leading to poor outcome

Eric O. Freed, Ph.D.

Director HIV Dynamics and Replication Program 
Head, Virus-Cell Interaction Section

Wednesday, April 17, 2024 | 12:00 PM (EST)

New advances in the study of HIV-1 assembly, maturation, and drug resistance

Mark B. Lewandoski, Ph.D.

Director Molecular Targets Program 
Head, Protein Chemistry And Molecular Biology Section

Wednesday, April 3, 2024 | 12:00 PM (EST)

The myriad functions of FGF signaling in vertebrate mesoderm induction and axis extension

Barry R. O'Keefe, Ph.D.

Senior Investigator Cancer and Developmental Biology Laboratory 
Head, Genetics Of Vertebrate Development Section

Wednesday, March 27, 2024 | 12:00 PM (EST)

Recent Developments in Natural Product Research

Erin L. Davies, Ph.D.

Stadtman Investigator Cancer and Developmental Biology Laboratory 
Head, Potency and Developmental Plasticity Section

Wednesday, March 13, 2024 | 12:00 PM (EST)

New invertebrate models for the study of adult stem cell-driven regeneration

Zoë Weaver Ohler, Ph.D.

Principal Scientist, Preclinical Evaluation Team Leader Center for Advanced Preclinical Research FNLCR

Wednesday, February 28, 2024 | 12:00 PM (EST)

TBA.

Lino Tessarollo, Ph.D.

Director Mouse Cancer Genetics Program 
Head, Neural Development Section

Wednesday, March 6, 2024 | 12:00 PM (EST)

Dissection of Neurotrophins function in Physiological and Pathological Conditions

Vineet KewalRamani, Ph.D.

Head Model Development Section Cancer Innovation Laboratory

Wednesday, February 21, 2024 | 12:00 PM (EST)

Shot to the heart: HIV trafficking to the cell nucleus.

Raj Chari, Ph.D.

Director Genome Modification Core

Wednesday, February 14, 2024 | 12:00 PM (EST)

Application of Genome Engineering Technologies in Cancer

Sandra Wolin, M.D., Ph.D

Head, Section on Noncoding RNAS and RNPS 
Head, National Cancer Institute RNA Biology Initiative

Wednesday, February 7, 2024 | 12:00 PM (EST)

Dealing with Difficult RNA.

Vinay Pathak, Ph.D.

Head, Viral Mutation Section HIV Dynamics and Replication Program 

Wednesday, January 31, 2024 | 12:00 PM (EST)

HIV-1 uncoating and nuclear import.

Marc Nicklaus, Ph.D.

Senior Scientist Chemical Biology Laboratory  
Head, Computer-Aided Drug Design (CADD) Group

Wednesday, January 24, 2024 | 12:00 PM (EST)

Synthetically Accessible Virtual Inventory (SAVI): On the way to trillions of molecules

Kedar Narayan, Ph.D.

Group Leader, Volume EM Group

Wednesday, January 17, 2024 | 12:00 PM (EST)

TBA.

Euna Yoo, Ph.D.

Stadtman Investigator Chemical Biology Laboratory Head, Chemical Immunology Section

Wednesday, January 10, 2024 | 12:00 PM (EST)

Dissecting immunomodulatory protease function using activity-based protein profiling and covalent ligand screening.

Terry Yamaguchi, Ph.D.

Head, Cell Signaling in Vertebrate Development Section

Wednesday, December 13, 2023 | 12:00 PM (EST)

TBA

Stephen Anderson, Ph.D.

Senior Investigator Cancer Innovation Laboratory Head, Molecular Immunology Section

Wednesday, November 29, 2023 | 12:00 PM (EST)

You “GATA” have switches to differentiate.

Allan Weissman, M.D.

Senior Investigator. Cancer Innovation Laboratory Head, Protein Homeostasis and Signaling Section

Wednesday, November 15, 2023 | 12:00 PM (EST)

Insights into Ubiquitinating Ligases and a SARS-CoV-2 Protease from Endoplasmic Reticulum-Associated Degradation.

Yinling Hu, Ph.D

Head, Inflammation and tumorigenesis Section Cancer Innovation Laboratory

Wednesday, October 25, 2023 | 12:00 PM (EST)

Opportunistic Candida albicans and Cladosporium Target EGFR Family Members, Tweak Innate Immune Responses, and Promote Carcinogenesis.

Wei-Shau Hu, Ph.D

Deputy Director Head, Viral Recomination Section HIV DRP

Wednesday, October 18, 2023 | 12:00 PM (EST)

The Regulation of HIV-1 RNA functions: it’s G-rated

Andy Stephen, Ph.D.

Group Lead RAS Biochemistry and Biophysics 
Leidos Biomedical Research, Inc. 
Frederick National Laboratory for Cancer Research

Wednesday, October 11, 2023 | 12:00 PM (EST)

Activation of RAF1 kinase by RAS proteins at the plasma membrane.

Scott Durum, Ph.D.

Head, Cytokines, and Immunity Section Cancer Innovation Laboratory

Wednesday, October 4, 2023 | 12:00 PM (EST)

Role of the IL-7 pathway in acute lymphoblastic leukemia.

Daniel McVicar, Ph.D.

Deputy Director, Center for Cancer Research 
Acting Chief, Cancer Innovation Laboratory 
National Cancer Institute-Frederick

Wednesday, September 20, 2023 | 12:00 PM (EST)

Metabolic Adaptations of Macrophages in Inflammation, Cancer, and Metabolic Disease

Bibliography

Shyam Sharan, Ph.D

Deputy Director, Senior Investigator, Head, Genetics of Cancer Susceptibility Section, Director, Center for Advanced Preclinical Research 
Mouse Cancer Genetics Program NCI/CCR

Wednesday, July 26, 2023 | 12:00 PM (EST) 

Making CRISPR sense of BRCA2 missense mutations using a high throughput functional assay

Bibliography

Mikhail Kashlev, Ph.D

Deputy Chief, Senior Investigator, Head, 
Molecular Mechanisms of Transcription Section 
RNA Biology Laboratory NCI/CCR

Wednesday, June 21, 2023 | 12:00 PM (EST) 

Bibliography

Chengkai Dai, Ph.D

Stadtman Investigator 
Head, Proteomic Instability of Cancer Section 
Mouse Cancer Genetics Program NCI/CCR

Wednesday, June 14, 2023 | 12:00 PM (EST) 

A Powerful Enabler of Oncogenesis: Implications of HSF1 in Proteomic Instability and Non-Oncogene Addiction of Cancer

Bibliography

Gregory Del Prete, Ph.D

Viral Persistence Section 
AIDS & Cancer Virus Program NCI/CCR

Wednesday, June 7, 2023 | 12:00 PM (EST) 

Development and Use of Simian-Tropic HIV-1: 
A Novel Nonhuman Primate Model of HIV-1 Infection

Bibliography

John Brognard, Ph.D

Head, Signaling Networks in Cancer Section 
Laboratory of Cell and Developmental Signaling NCI/CCR

Wednesday, May 24, 2023 | 12:00 PM (EST)

Cancers of Unmet Need: New Targets, New Drugs, and the Creation of a Biotech Startup

Bibliography

Alexander Wlodawer, Ph.D

Head, Protein Structure Section 
Center for Structural Biology NCI/CCR

IN PERSON ONLY - NCI Frederick Auditorium

Wednesday, May 17, 2023 | 12:00 PM (EST) 

Many secrets of L-asparaginase, the oldest protein-based cancer drug

Bibliography

Peter F. Johnson, Ph.D

Head, Eukaryotic Transcriptional Regulation Section 
Mouse Cancer Genetics Program NCI/CCR

Wednesday, May 10, 2023 | 12:00 PM (EST) 

Novel features of oncogenic signal transduction involving mRNA localization and signaling endosomes

Bibliography

Matthew T. Wolf, Ph.D

Stadtman Investigator 
Head, Cancer Biomaterials Engineering Section 
Cancer Innovation Laboratory NCI/CCR

Wednesday, May 3, 2023 | 12:00 PM (EST) 

Bibliography

Kylie Walters, Ph.D

Head, Protein Processing Section 
Center for Structural Biology NCI/CCR

IN PERSON ONLY - NCI Frederick Auditorium

Wednesday, March 29, 2023 | 12:00 PM (EST)

A Tale of Two Proteasome Substrate Receptors: 
Interactions and Therapeutic Opportunities

Bibliography

Ping Zhang, Ph.D.

Head, Kinase Complex Section 
Center for Structural Biology NCI/CCR

Wednesday, March 22, 2023 |12:00 PM (EST)

Revealing Molecular Assemblies of Kinase Signaling Complexes: ConnecKng Structure and Mechanism 

Bibliography

Kathrin Muegge, M.D.

Head, Epigenetics Section 
Mouse Center Genetics Program NCI/CCR

Wednesday, March 15, 2023 |12:00 PM (EST)

The role of the chromatin remodeler LSH in the ICF4 syndrome

Professor Yifat Merbl, Ph.D.

Principal Investigator, The Merbl Laboratory 
Dept. of Systems Immunology, Weizmann Institute of Science

Wednesday, March 8, 2023 |12:00 PM (EST)

Novel insight into tumor immunogenicity through the lens of the epiProteome

Bibliography

Xinhua Ji, Ph.D.

Head, Biomolecular Structure Section 
Center for Structural Biology NCI-Frederick

Wednesday, February 18, 2023 |12:00 PM (EST)

Structural view of dsRNA processing by RNase III enzymes: Sequence specificity, ruler-based mechanism, and cleavage site assembly 

Bibliography

Alex Compton, Ph.D.

Head, Antiviral Immunity and Resistance Section 
HIV Dynamics and Replication Program NCI-Frederick

Wednesday, February 8, 2023 |12:00 PM (EST)

Mechanisms of cell-intrinsic antiviral immunity

Bibliography

Nadya Tarasova, Ph.D.

Synthetic Biologics Facility 
Cancer Innovation Laboratory NCI-Frederick.

Wednesday, December 14, 2022 |12:00 PM (EST)

Moving from computer-aided to computer-driven molecular discovery

Frank Maldarelli, M.D., Ph.D.

Wednesday, November 30, 2022 |12:00 PM (EST)

HIV Persistence in Anatomic Compartments During Antiretroviral Therapy: A View From the Fridge

Bibliography

Terrence R. Burke Jr., Ph.D.

Bioorganic Chemistry Section 
Chemical Biology Laboratory NCI-Frederick.

Wednesday, November 16, 2022 |12:00 PM (EST)

Viewing HIV-1 Integrase Through a Chemistry Lens

Bibliography

Susan Mackem, M.D., Ph.D.

Regulation of Vertebrate Morphogenesis Section 
Cancer and Developmental Biology Laboratory NCI-Frederick.

Wednesday, November 2, 2022 |12:00 PM (EST)

Balancing robustness and control:  why Shh is so highly dynamic in the limb and relevance for proliferation

Bibliography

John Beutler, Ph.D.

Head, Chemical Diversity Development Section 
Molecular Targets Program NCI-Frederick.

Hunting bioactive natural products in Kazakhstan

Bibliography

John J. Schneekloth, Jr., Ph.D.

Head, Chemical Genetics Section 
Chemical Biology Laboratory NCI-Frederick.

Developing the Tools to Target RNA with Small Molecules

Website Link

Bibliography

Stephen Lockett, Ph.D.

Optical Microscopy and Analysis Laboratory NCI-Frederick.

Understanding Immune Suppression and Invasion in Tumors