Thursday, October 25, 2018

08:30 am - 09:00 am EST
Pick up badge, Pay for dinner ticket, Setup posters
09:00 am - 09:10 am EST
Welcome, Introduction, Purpose of the Meeting and Meeting Rules

Session 1 - IFN-λ Biology, Therapy and Genetic Variation

Moderators – Howard Young, Rune Hartmann

09:10 am - 09:35 am EST
Raymond Donnelly, Center for Drug Evaluation and Research, Food and Drug Administration, USA

An Overview of the IFN-λ Proteins and Their Biological Functions

09:35 am - 10:00 am EST
Jeffrey Glenn, Department of Gastroenterology, Stanford University School of Medicine, USA

Trials of IFN-λ1 in Chronic Hepatitis Virus Infections

10:00 am - 10:25 am EST
Juan Mendoza, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, USA

Structure and Engineering of an IFN-λ Receptor Complex Provides a Blueprint for Developing the Next Generation IFN-λ Therapeutics

10:25 am - 10:45 am EST
Coffee Break - (Courtesy of FAES)
10:45 am - 11:10 am EST
Ludmila Prokunina-Olsson, Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA

IFNL4 Discovery and Genetics

11:10 am - 11:35 am EST
Connor Bamford, MRC-University of Glasgow Centre for Virus Research, UK

Selected Talk - A Polymorphic Residue That Attenuates the Antiviral Potential of Interferon Lambda 4 in Hominid Lineages

Session 2 - IFN-λ and HCV Infection Moderators – Barbara Rehermann, Jacob George

11:35 am - 12:00 pm EST
Thomas O’Brien, Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA

What Have We Learned from Studies of IFN-λ Variants and HCV?

12:00 pm - 12:25 pm EST
Vincent Pedergnana, Human Genetics, Genome Institute of Singapore

Broad Impact of Interferon Lambda 4 on Hepatitis C Virus Diversity

12:15 pm - 02:00 pm EST
Lunch / Poster Session
02:00 pm - 03:20 pm EST
How does IFN-λ impair HCV clearance? Presentations/panel discussion:

Do Genetic Polymorphisms within the IFNL4 Gene Influence the Transcription of the IFNL3 Gene? - Rune Hartmann, Department of Molecular Biology and Genetics, Aarhus University, Denmark


Interferon Lambda 4 Accumulates in the Endoplasmatic Reticulum and Causes ER Stress - Markus Heim, Department of Biomedicine, University of Basel, Switzerland

Collaborative Roles of Type I and III Interferons in Viral Restriction - Ram Savan, Department of Immunology, University of Washington, USA

03:20 pm - 03:40 pm EST
Coffee Break (Courtesy of FAES)

Session 3 - IFN-λ - Hepatic Fibrosis and Cancer Moderators - Thomas O’Brien, Ludmila Prokunina-Olsson

03:40 pm - 04:05 pm EST
Jacob George, Storr Liver Centre, Westmead Institute for Medical Research / University of Sydney School of Medicine, Australia

Association of IFN-λ Variants with Viral and Non-Viral Hepatic Fibrosis

04:05 pm - 04:30 pm EST
Olusegun Onabajo, Division of Cancer Epidemiology and Genetics, NCI, USA

IFNL3/IFNL4 Locus Genotype is Associated with HCV+ Liver Cancer and Enrichment of Mutations in the WNT Signaling Pathway

04:30 pm - 04:55 pm EST
Linda Kelemen, Department of Public Health Sciences, The Medical University of South Carolina, USA

A Genetic Variant Near IFNL3 Associates with Mucinous Ovarian Carcinoma

04:55 pm - 05:30 pm EST
Tsion Minas, Center for Cancer Research, National Cancer Institute, USA

 IFNL4 in Prostate Cancer: Association with Sexually Transmitted Infections, Survival and Interferon Signature in Tumors

Administrative remarks as needed

Friday, October 26, 2018

Session 4 – IFN-λ in Other Infections Moderators – Kim Green, Eric Meissner, Raymond Donnelly

09:00 am - 09:25 am EST
Carolyn Coyne, University of Pittsburgh School of Medicine, USA

Type III IFN Signaling in Placental Antiviral Defenses

09:25 am - 09:50 am EST
Helen Lazear, Department of Microbiology and Immunology, UNC School of Medicine, USA

IFN-λ and Viral Invasion Across Anatomic Barriers

09:50 am - 10:15 am EST
Jonathan Kagan, Harvard Medical School, USA

IFN-λ and Bacterial Infections

10:15 am - 10:35 am EST
Coffee Break (Courtesy of FAES)
10:35 am - 11:00 am EST
Megan Baldridge, Washington University School of Medicine, USA

Regulation of Persistent Murine Norovirus Infection by the Microbiota and IFN-λ

11:00 am - 11:15 am EST
Ivan Zanoni, Harvard Medical School, USA

Selected Talk - Type III Interferons Regulate Intestinal Inflammation

11:15 am - 11:40 am EST
Sergei Kotenko, New Jersey Medical School, USA

IFN-λ in Gastrointestinal Infections and Homeostasis

11:40 am - 12:30 pm EST
12:30 pm - 12:55 pm EST
Evangelos Andreakos, Center for Clinical and Translational Research, Biomedical Research Foundation, Academy of Athens, Greece

IFN-λs Fine-Tune Front Line Antiviral Immunity Against Influenza Virus Infection for Optimal Protection and Minimal Host Damage

12:55 pm - 01:20 pm EST
Peter Staeheli, Institute of Virology, Department for Medical Microbiology and Hygiene, University of Freiburg, Germany

IFN-λ Enhances Adaptive Antiviral Immunity by Boosting TSLP Release Upon Mucosal Immunization

01:20 pm - 01:35 pm EST
Emily Hemann, University of Washington, USA

Selected Talk – IFN-λ Directs Migratory Dendritic Cell Function to Orchestrate T Cell Immunity During Influenza Virus Infection

01:35 pm - 01:45 pm EST
Closing Remarks
01:45 pm - 02:30 pm EST
Bonus Session

Roundtable Discussion on Extramural Funding


Moderators – Danielle Carrick(NCI) and Rudy Alarcon

Conference Ends