Overview
Virtual
This is a virtual meeting via WebEx and registration is now closed.
Cellular senescence has typically been defined as irreversible cell growth arrest and is an essential tumor-suppressive mechanism that prevents the propagation of genetically unstable and damaged cells and promotes their removal by the immune system. Induction of cancer cell senescence is also one of the essential underlying mechanisms by which radiation and chemotherapy exert their anti-tumor activity as they can activate not only many cell-signaling, proapoptotic, pro-survival, and tumorigenic molecular pathways, but also cause premature senescence; a striking intersection that may be shared and pivotal in controlling and regulating cancer and senescence. The goal of this workshop is to provide a forum for the leading investigators in radiation treatment, senescence, and cancer research fields to discuss the current status of senescence research and senotherapeutics in relation to chemoradiation. The speakers will identify the key gaps of knowledge in the discovery, development, and translation of senotherapeutics for clinical use.
Meeting Organizers
Radiation Research Program (RRP), Division of Cancer Treatment and Diagnosis (DCTD), NCI
Pataje G. Prasanna, PhD.
C. Norman Coleman, MD.
Center for Cancer Research (CCR), NCI
Deborah E. Citrin, MD.
University of Florida, Gainesville, FL
Daohong Zhou, PhD.