Agenda

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Monday, August 10, 2020

09:15 am - 09:40 am EST
Virtual arrival
09:40 am - 09:50 am EST
Logistics, background, and charge for the meeting

Pat G. Prasanna, NCI

09:50 am - 10:00 am EST
Welcome & Introduction of the Keynote Speaker

C. Norman Coleman, NCI

 

 

10:00 am - 10:35 am EST
Keynote speaker

Dynamic interplay between senescence and cancer; Ned Sharpless, Director, NCI

Session I: Hallmarks of Cellular Senescence and Cancer

Moderators: Jeffrey Hildesheim, NCI, and Jan van Deursen, Mayo Clinic

10:40 am - 10:55 am EST
Senescent cells as both drivers and suppressors of radiation-induced cancers

Judith Campisi, Buck Institute, Novato, CA

10:55 am - 11:10 am EST
Animals models to study the role of senescence cells in diseases and cancer

Jan van Deursen, Mayo Clinic, Rochester, MN

11:10 am - 11:25 am EST
Radiation, senescence, and diseases

Stephen Brown; Henry Ford Health Systems, Detroit, MI

11:25 am - 11:40 am EST
Senolytic and senomorphic therapy

Laura Niedernhofer, University of Minnesota, Minneapolis, MN

11:40 am - 12:00 pm EST
Panel Discussion
Session II: Molecular Mechanisms of Senescence

Moderators: Mansoor M Ahmed, NCI, and Jorg Goronzy, Standford

12:00 pm - 12:15 pm EST
Intercellular communication in senescence and aging

Ana O’Loghlen, Queen Mary University, London, UK

12:15 pm - 12:30 pm EST
DNA damage response regulating senescence and immune response

Alexandros Georgakilas, National Technical University of Athens, Greece

12:30 pm - 12:45 pm EST
Immunosenescence

Jorg Goronzy, Stanford University, CA

12:45 pm - 01:05 pm EST
Panel Discussion
01:05 pm - 01:45 pm EST
Lunch
Session III: Metabolic and Epigenetic Mechanisms

Moderators: Pataje Prasanna, NCI and Stephen Kron, University of Chicago

01:45 pm - 02:00 pm EST
Long-term senescence in endothelial cells through mitochondrial respiratory complex dysfunction

Francois Paris, University of Nantes, Nantes, France

02:00 pm - 02:15 pm EST
Sirt family of proteins in the modulation of ROS, carcinogenesis, and aging

David Gius, Northwestern University, Chicago, IL

02:15 pm - 02:30 pm EST
Escape from chemotherapy and radiation-induced senescence: Impact of senolytics and tumor dormancy

David Gewirtz, Virginia Commonwealth University, Richmond, VA

02:30 pm - 02:45 pm EST
Chromatin dynamics and cell-cycle regulation in DNA damage checkpoint response and senescence

Stephen Kron, University of Chicago, Chicago, IL

02:45 pm - 03:05 pm EST
Panel Discussion & Wrap Up Day 1

Tuesday, August 11, 2020

09:15 am - 09:30 am EST
Arrival
Session V: Radiation, Senescence, and Tissue Remodeling

Moderators: Michael Espey and Deborah Citrin, NCI

09:30 am - 09:45 am EST
Mechanistic insights into the plasticity of cancer cells

Clemens A Schmitt, Charité – Universitätsmedizin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

09:45 am - 10:00 am EST
Cellular plasticity, minimal residual disease, and tumor recurrence in cancer

Mohamed Abazeed, Northwestern University, Chicago, IL

10:00 am - 10:15 am EST
Radiation-induced premature senescence

Daohong Zhou, University of FL, Gainesville, FL

10:15 am - 10:30 am EST
Radiation, senescence, and tissue fibrosis

Deb Citrin, NCI

10:30 am - 10:50 am EST
Panel Discussion
Session VI: “One-Two Punch” Cancer Therapy

Moderators: Sundar Venkatachalam, NCI and Daohong Zhou, University of FL

10:50 am - 11:05 am EST
Clinical translation of senotherapeutics

James Kirkland, Mayo Clinic, Rochester, MN

11:05 am - 11:25 am EST
The SASP associated with therapy-induced senescence recruits antitumor TILS into the tumor microenvironment

Ann Richmond, Vanderbilt University, Nashville, TN

11:25 am - 11:45 am EST
Cancer therapy, senescence, and antitumor immunity

Paul Romesser and Scott Lowe, Memorial Sloan Kettering Institute, New York, NY.

11:40 am - 11:55 am EST
Strategies to target senescence

Jesus Gil, MRC Imperial College, London, UK.

11:55 am - 12:15 pm EST
Panel Discussion
12:15 pm - 12:45 pm EST
Lunch
Session IV: Development of Senotherapeutics

Moderators: Gabriela Riscuta, NCI and Dan Xi, NCI

12:45 pm - 01:00 pm EST
Discovery and development of senotherapeutic agents for clinical translation

Guangrong Zheng, University of FL, Gainesville, FL

01:00 pm - 01:15 pm EST
Chemoprevention and senescence

Marc Mendonca, Indiana University, Indianapolis, IN

01:15 pm - 01:30 pm EST
Prevention of glioblastoma recurrence after radiotherapy by the elimination of senescent astrocytes

Sundeep Burma, University of Texas Health, San Antonio, TX

01:30 pm - 01:45 pm EST
Regulatory considerations

Mitchell Anscher, Food and Drug Administration, Silver Spring, MD

01:45 pm - 02:00 pm EST
Panel Discussion
02:00 pm - 02:30 pm EST
General Discussion, Next Steps, Adjourn

Moderators: Deb Citrin, CCR, NCI and Daohong Zhou, University of FL, Gainesville, FL