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  1. 1.   A selective small-molecule nuclear factor-kappa B inhibitor from a high-throughput cell-based assay for "activator protein-1 hits"
  2. Kang, M. I.; Henrich, C. J.; Bokesch, H. R.; Gustafson, K. R.; McMahon, J. B.; Baker, A. R.; Young, M. R.; Colburn, N. H.
  3. Molecular Cancer Therapeutics. 2009 8(3): 571-581.
  1. 2.   JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells
  2. Yin, Y. M.; Wang, S.; Sun, Y. J.; Matt, Y.; Colburn, N. H.; Shu, Y. Q.; Han, X.
  3. Biomedicine and Pharmacotherapy. 2009 63(6): 429-435.
  1. 3.   Targeting the Activator Protein 1 Transcription Factor for the Prevention of Estrogen Receptor-Negative Mammary Tumors
  2. Shen, Q.; Uray, I. P.; Li, Y. X.; Zhang, Y.; Hill, J.; Xu, X. C.; Young, M. R.; Gunther, E. J.; Hilsenbeck, S. G.; Colburn, N. H.; Chodosh, L. A.; Brown, P. H.
  3. Cancer Prevention Research. 2008 1(1): 45-55.
  1. 4.   Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies
  2. Wei, Q.; Jiang, H.; Matthews, C. P.; Colburn, N. H.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2008 105(50): 19738-19743.
  1. 5.   AP-1 a target for cancer prevention
  2. Matthews, C. P.; Colburn, N. H.; Young, M. R.
  3. Current Cancer Drug Targets. 2007, Jun; 7(4): 317-324.
  1. 6.   Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis
  2. Matthews, C. P.; Birkholz, A. M.; Baker, A. R.; Perella, C. M.; Becky, G. R.; Young, M. R.; Colburn, N. H.
  3. Cancer Research. 2007, Mar; 67(6): 2430-2438.
  1. 7.   Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages
  2. Kim, S. H.; Lee, S.; Suk, K.; Bark, H.; Jun, C. D.; Kim, D. K.; Choi, C. H.; Yoshimura, T.
  3. Free Radical Biology and Medicine. 2007, Feb; 42(3): 343-352.
  1. 8.   Fra-1 a target for cancer prevention or intervention
  2. Young, M. R.; Colburn, N. H.
  3. Gene. 2006, Sep; 379: 1-11.
  1. 9.   Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
  2. Yang, H. S.; Matthews, C. P.; Clair, T.; Wang, Q.; Baker, A. R.; Li, C. C. H.; Tan, T. H.; Colburn, N. H.
  3. Molecular and Cellular Biology. 2006, Feb; 26(4): 1297-1306.
  1. 10.   Growth arrest-inducing genes are activated in Dbl-transformed mouse fibroblasts
  2. Melani, R.; Sallustio, F.; Fardin, P.; Vanni, C.; Ognibene, M.; Ottaviano, C.; Melillo, G.; Varesio, L.; Eva, A.
  3. Gene Expression. 2006 13(3): 155-165.
  1. 11.   Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell line
  2. Song, X.; Tao, Y. G.; Zeng, L.; Deng, X. Y.; Lee, L. M.; Gong, J. P.; Wu, Q.; Cao, Y.
  3. Virus Research. 2005, NOV; 113(2): 89-99.
  1. 12.   Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers
  2. Song, X.; Tao, Y. G.; Zeng, L.; Yang, J.; Tang, F. Q.; Lee, L. M.; Gong, J. P.; Wu, Q.; Cao, Y.
  3. Science in China Series C-Life Sciences. 2005, AUG; 48(4): 385-393.
  1. 13.   Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress
  2. Qu, W.; Diwan, B. A.; Reece, J. M.; Bortner, C. D.; Pi, J. B.; Liu, J.; Waalkes, M. P.
  3. International Journal of Cancer. 2005, APR 10; 114(3): 346-355.
  1. 14.   Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
  2. Yamashita, M.; Ying, S. X.; Zhang, G. M.; Li, C. L.; Cheng, S. Y.; Deng, C. X.; Zhang, Y. E.
  3. Cell. 2005, APR 8; 121(1): 101-113.
  1. 15.   The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level
  2. Qu, W.; Liu, J.; Fuquay, R.; Shimoda, R.; Sakurai, T.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Nitric Oxide-Biology and Chemistry. 2005, MAR; 12(2): 114-120.
  1. 16.   Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1
  2. Song, X.; Tao, Y. G.; Tan, Y. N.; Lee, L. M.; Deng, X. Y.; Wu, Q.; Cao, Y.
  3. Science in China Series C-Life Sciences. 2005, FEB; 48(1): 70-80.
  1. 17.   Inhibition of melanoma growth and metastasis by ATF2-derived peptides
  2. Bhoumik, A.; Gangi, L.; Ronai, Z.
  3. Cancer Research. 2004, NOV 15; 64(22): 8222-8230.
  1. 18.   Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development
  2. Lee, S. Y.; Lee, F. S.; Moon, J. S.; Kim, J. I.; Park, J. B.; Lee, J. Y.; Park, M. J.; Kim, J.
  3. Experimental and Molecular Medicine. 2004, OCT 31; 36(5): 468-475.
  1. 19.   NF-kappa B activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NF kappa B regulatory site in autocrine human multiple myeloma cells
  2. Xiao, W. H.; Hodge, D. R.; Wang, L. H.; Yang, X. Y.; Zhang, X. H.; Farrar, W. L.
  3. Cancer Biology & Therapy. 2004, OCT; 3(10): 1007-1017.
  1. 20.   Contribution of JNK, Mek, Mos and PI-3K signaling to GVBD in Xenopus oocytes
  2. Mood, K.; Bong, Y. S.; Lee, H. S.; Ishimura, A.; Daar, I. O.
  3. Cellular Signalling. 2004, MAY; 16(5): 631-642.
  1. 21.   Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms
  2. Hou, D. X.; Kai, K.; Li, J. J.; Lin, S. G.; Terahara, N.; Wakamatsu, M.; Fujii, M.; Young, M. R.; Colburn, N.
  3. Carcinogenesis. 2004 25(1): 29-36.
  1. 22.   Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug
  2. Findlay, V. J.; Townsend, D. M.; Saavedra, J. E.; Buzard, G. S.; Citro, M. L.; Keefer, L. K.; Ji, X. H.; Tew, K. D.
  3. Molecular Pharmacology. 2004 65(5): 1070-1079.
  1. 23.   Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation
  2. Dhar, A.; Hu, J.; Reeves, R.; Resar, L. M. S.; Colburn, N. H.
  3. Oncogene. 2004 23(25): 4466-4476.
  1. 24.   Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase
  2. Nishigaki, K.; Thompson, D.; Yugawa, T.; Rulli, K.; Hanson, C.; Cmarik, J.; Gutkind, J. S.; Teramoto, H.; Ruscetti, S.
  3. Journal of Biological Chemistry. 2003 278(15): 13520-13530.
  1. 25.   Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP- 1 transactivation
  2. Yang, H. S.; Knies, J. L.; Stark, C.; Colburn, N. H.
  3. Oncogene. 2003 22(24): 3712-3720.
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