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Allostery modulates the beat rate of a cardiac pacemaker

  1. Author:
    Tsai, Chung-Jung
    Nussinov, Ruth

  2. Author Address

    From the Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702 and., From the Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702 and NussinoR@mail.nih.gov., Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.,
    1. Year: 2017
    2. Date: Apr 14
  2. Journal: The Journal of Biological Chemistry
    1. 292
    2. 15
    3. Pages: 6429-6430
  4. Type of Article: Article
  5. Article Number: 6429-6430
  1. Abstract:

    The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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External Sources

  1. View Full Text
  2. DOI: 10.1074/jbc.H116.773697
  3. PMID: 28411213
  4. PMCID: PMC5391769
  5. View record in Web of Science®
  6. WOS: 000399538700034

Library Notes

  1. Fiscal Year: FY2016-2017
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