Download the agenda here.

Download the Abstract Book here.

Wednesday, September 27, 2023

08:30 am EST
Welcome Remarks

Glenn Merlino, Ph.D., Scientific Director for Basic Research, Center for Cancer Research, NCI

08:40 am EST
Welcome Remarks


Immune Cell Development, Thymus-Style
Chairs: Christian Mayer, Ph.D., and Stanley Adoro, Ph.D.

08:45 am EST
Transcriptional Determination of T lineage Fate

Alfred Singer, M.D., Center for Cancer Research, NCI

09:05 am EST
CD4 T Cell Differentiation, in the Thymus and Beyond

Rémy Bosselut, M.D., Ph.D., Center for Cancer Research, NCI

09:25 am EST
Thymic formation of CD8 T Cell Repertoire

Yousuke Takahama, Ph.D., Center for Cancer Research, NCI

09:45 am EST
The Anatomy, Regulation, and Function of Glucocorticoids Produced in the Thymus

Jonathan Ashwell, M.D., Center for Cancer Research, NCI

10:05 am EST
10:35 am EST
The Role of the Transcription Factor, BRD4, in Thymic Development

Dinah Singer, Ph.D., Center for Cancer Research, NCI

10:55 am EST
Notch1 sets the molecular clock for T-Cell Development

Roxane Tussiwand, Ph.D., Center for Cancer Research, NCI

11:05 am EST
Gene Regulatory Mechanisms Establishing T-Cell Identity

Ellen Rothenberg, Ph.D., California Institute of Technology

11:30 am EST


Immunity-Pathophysiology Crosstalk
Alfred Singer, M.D., and Avinash Bhandoola, Ph.D.


12:45 pm EST
Not Done Yet: Unexpected Facets of Complement Activities in Cell Physiology

Claudia Kemper, Ph.D., National Heart, Lung, and Blood Institute, NIH

01:05 pm EST
Immune-Mediated Mechanisms of Adaptive and Maladaptive Tissue Responses

Shruti Naik, Ph.D., New York University

01:30 pm EST
EGR2: Steering Pathogenic Th17 Cell Function in CNS Autoimmune Disease

Vanja Lazarevic, Ph.D., Center for Cancer Research, NCI

01:50 pm EST
Immune calibration of neuroendocrine homeostasis

Chuan Wu, M.D., Ph.D., Center for Cancer Research, NCI

02:10 pm EST
Neuroimmune Interactions in Enteric Nervous System

Vijay Kuchroo, DVM., Ph.D., Harvard Medical School

02:35 pm EST

Session 3

Cancer Immunology: Part 1
Chairs: Pamela L Schwartzberg, M.D., Ph.D. and Hyun Park, Ph.D.

03:05 pm EST
The role of the Intestinal Microbiome in Cancer Immunotherapy

Marcel van den Brink, M.D., Ph.D., Memorial Sloan Kettering Cancer Center

03:30 pm EST
Understanding Microbiota Regulation of the Tumor Microenvironment and Response to Cancer Therapy

Romina Goldszmid, Ph.D., Center for Cancer Research, NCI

03:50 pm EST
Turning the Table on Oncogenic Herpesviruses: Vaccination with a Gammaherpesvirus with Targeted Mutations in Genes Required for Replication and Latency Protects Against Wild-Type Virus Pathogenesis in the Host

Laurie Krug, Ph.D., Center for Cancer Research, NCI

04:10 pm EST
Discovery of Novel Epigenetic Mechanisms that Control T Cell-Mediated Tumor Immunity

Kai Wucherpfenning, M.D., Ph.D., Dana-Faber Cancer Institute

Thursday, September 28, 2023


Innate Immunity
Chairs: Romina Goldszmid, Ph.D., and 
Vanya Lazarevic, Ph.D.


08:30 am EST
Innate Lymphoid Cells: Development, Differentiation and Dynamics

James Di Santo, M.D., Ph.D., Pasteur Institute

08:55 am EST
Different Developmental Pathways Generate Functionally Distinct Populations of Natural Killer Cells

Avinash Bhandoola, M.D., B.S., Ph.D., Center for Cancer Research, NCI

09:15 am EST
The Cytokine Receptor DR3 Controls iNKT Cell Immunity

Hyun Park, Ph.D., Center for Cancer Research, NCI

09:35 am EST
Memory Responses by Innate T Cells

Mitchell Kronenberg, Ph.D., La Jolla Institute for Immunology

10:00 am EST
Regulation of Barrier Immunity

David Artis, Ph.D., Cornell Weill Medical School



Immune Cell Signaling
Laurie Krug, Ph.D., and Jonathan Ashwell, M.D.


10:55 am EST
Dynamic Membrane Changes Controlling TCR Signaling

Gillian Griffiths, FMedSci, FRS, Cambridge University

11:20 am EST
Apoptosis and B Lymphocyte Repertoire Selection

Christian Mayer, Ph.D., Center for Cancer Research, NCI

11:40 am EST
Defining the Role of Lck-Coreceptor Association in T cell Receptor Signaling and Fate Specification

Nicole La Gruta, Ph.D., Monash University

12:05 pm EST
Formation of the Tetrameric Protein Complex Containing Phospholipase-Cg1 During T Cell Activation

Lawrence Samelson, M.D., Center for Cancer Research, NCI

12:25 pm EST


Immune Cell Function
Daniel McVicar, Ph.D., and Chuan Wu, M.D., Ph.D.


01:40 pm EST
PI3 Kinase and Balancing T Cell Activation Under Exhaustion

Pamela Schwartzberg, M.D., Ph.D., National Institute of Allergy and Infectious Diseases, NIH

02:00 pm EST
A Proteostasis Link to Cell Autonomous T Cell Dysfunction

Stanley Adoro, Ph.D., Center for Cancer Research, NCI

02:20 pm EST
Nutrient Driven Proliferation in Mucosal Germinal Centers

Jagan Muppidi, M.D., Ph.D., Center for Cancer Research, NCI

02:40 pm EST


Cancer Immunology: Part 2
Chairs: Dinah Singer, Ph.D., and 
Jagan Muppidi, M.D., Ph.D.


03:10 pm EST
LAG3: The Third Checkpoint Inhibitor

Dario Vignali, Ph.D., University of Pittsburg

03:35 pm EST
A Role for Acod1-Mediated Itaconate in Cancer and Metabolic Disease

Daniel McVicar, Ph.D., Center for Cancer Research, NCI

03:55 pm EST
Steering Cancer Immunotherapies in the High Dimensional Space of Leukocyte Activation

Grégoire Altan-Bonnet, Ph.D., Center for Cancer Research, NCI

04:15 pm EST
Metabolic Crosstalk in T Lymphocyte Effector Function

Naomi Taylor, M.D., Ph.D., Center for Cancer Research, NCI

04:35 pm EST
Closing Remarks