Agenda
Monday, January 29, 2024
Gregoire Altan-Bonnet, NCI
"We need to talk about cross-presentation. Really, we do."
*refreshments available
Chairs: Joanna Bandola-Simon (NCI) & Hyun Park (NCI)
Talk 1: Can Li (NCI)
"CD103 Preconditions Naive CD8 T Cells for Their Acquisition of Effector Phenotype and Function"
Talk 2: Sooraj Achar (NCI)
"Antagonism-enforced braking system to enhance CAR T cell therapeutic specificity"
Speed Talk 1: Jyh Lian Hor (CI)
"PD-1/cDC1 axis in the tumor draining lymph node regulates stem-like CD8+ T cell differentiation"
Speed Talk 2: Natalie D. Convertino (NCI)
"Weak Interaction Between SLP-76 and PLC-g1 Within Heterotetrameric Circular Complex Upon TCR Engagement Fine-Tunes TCR-Signal and Strength"
Speed Talk 3: Guillaume Gaud (NICHD)
"An unexpected inhibitory role for CD3z ITAMs: Implications for TCR signaling and application to tumor-immunotherapy"
Chairs: John O'Shea (NIAMS) & Stefan Muljo (NIAID)
Talk 1: Justin Shayne (NIAMS)
"A novel regulatory element, +6.5kbll13, regulates the enhancer landscape and controls chromatin architecture of the Type 2 cytokine locus"
Talk 2: Jennifer Cannons (NIAID)
"PI3K delta coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells differentiation during acute and chronic viral infections"
Speed Talk 1: Suyasha Roy (NHLBI)
"Blimp-1 negatively regulates IL-2 signaling in T cells"
Speed Talk 2: Shahar Azar (NIDDK)
"Wild-Derived Microbiota Protect Against Diet-Induced Obesity via an Immune-Medicated Effect on Brown Adipocytes"
RRBITC cafeteria, downtown restaurants, food trucks
1:00pm-2:00pm Even number presenters
2:00pm-3:00pm Odd number presenters
Chairs: Eric Dang (NIAID) & Lydia Roberts (NIAID)
Talk 1: Alex Clark (NCI)
"Spatial Transcriptomic Profiling Technologies highlight the importance of T cell tissue localization in the immune response against chronic infections of the brain"
Talk 2: Motoyoshi Nagai (NIAID)
"Dietary factors and skin microbes govern skin homeostasis via regulating would healing"
Speed Talk 1: Ashira Lubkin (NIAID)
"Candida albicans pathogenesis in mucosal type II interferonopathy"
Speed Talk 2: Brigette Boast (NIH CC)
"Germline multimorphic Irf4T95R variant confers susceptibility to Pneumocystis pneumonia in humans and mice"
Speed Talk 3: Aline Sardinha-Silva (NIAID)
"A gastrointestinal protist reshapes mucosal immunity toward a Type-2 response that attenuates inflammatory bowel-like diseases"
Chairs: Julie Fox (NIAID) & Michael Sacks (NHLBI)
Talk 1: Erin West (NHLBI)
“Dysregulation of T cell intrinsic C5aR2 activation causes uncontrolled inflammatory Th responses and autoinflammatory syndrome”
Speed Talk 1: Ngoc Thuy Nguyen (NCI)
“Type I interferon and IL27 modulate regulatory T cells in a Lupus-prone mouse model”
Speed Talk 2: Brooke Boyd (NIAMS)
“Elucidating the molecular mechanisms of a novel mutation in IRAK2 in systemic juvenile idiopathic arthritis (sJIA)”
Chairs: Sabina Kaczanowska (NCI) & Ronit Mazor (FDA)
Talk 1: Benjamin Angeles (NCI)
“Generation of novel anti-tumor chimeric antigen receptors incorporating downstream T- cell signaling proteins”
Talk 2: Stephen Migueles (NIAID)
“HIV vaccines induce CD8+T cells with low antigenreceptor sensitivity”
Speed Talk 1: Zhijian Duan (NCI)
“CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 for treating cervical cancer”
Speed Talk 2: Sojin Bing (FDA)
“Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus”
Speed Talk 3: Taisuke Kondo (NCI)
“Harnessing arginine metabolism overcomes hyperthermia-induced metabolic dysfunction of CAR T-cells”
5:00pm-6:00pm Odd number presenters
6:00pm-7:00pm Even number presenters
*food & refreshments available - cash bar
Tuesday, January 30, 2024
Chairs: Barbara Rehermann (NIDDK) & Li Yang (NCI)
Talk 1: Julie Fox (NIAID)
“Antibody effector functions for optimal protection against alphaviruses”
Talk 2: Eric Dang (NIAID)
“Immunity to fungi at barrier tissues”
Talk 3: Hao Jin (NIAID)
"Body-brain axis in the control of immunity"
Talk 4: Meera Murgai (NCI)
“Uncovering Perivascular Niche Dynamics in Metastasis”
Talk 5: Kazusa Ishii (NCI)
"CD22 TCR-Engineered T Cells Exert Anti-Leukemia Cytotoxicity Without Causing Inflammatory Responses"
Talk 6: Sri Krishna (NCI)
“Phenotypic heterogeneity of antitumor T cells in patients with metastatic cancer”
*refreshments available
Chairs: Gregoire Altan-Bonnet (NCI) & Julia Gross (NIAID)
Talk 1: Javeed Ahmad (NIAID)
“Structure-guided design and Characterization of Bivalent molecules against SARS-CoV-2”
Talk 2: Nathan Manes (NIAID)
“Data-Driven Modeling of the Mouse Macrophage Toll-like Receptor Signaling Pathway”
Speed Talk 1: Shil Patel (NCI)
“Utilizing spatial transcriptomics to study fate decisions and lineage specification during T cell development”
Speed Talk 2: Preeyaporn Songkiatisak (NIA)
“Exploring the roles of NF-kB in Alzheimer’s Disease using APOE risk-associated brain models in vitro”
Chairs: Jay Berzofsky (NCI) & Daniela Verthelyi (FDA)
Talk 1: Yongjun Sui (NCI)
“Innate protection against intrarectal SIV acquisition by a live Simian-Human immunodeficiency virus vaccine”
Talk 2: Dragana Jankovic (NIAID)
“Microbial-ligand independent regulation of lymphopoiesis by NOD1”
Speed Talk 1: Chloe Hicks (NIAID)
“Xanthine Oxidase Regulation of Gasdermin D: Developing Biosensors to Assess Cleavage-Activated Signaling Events”
Speed Talk 2: Ian Bettencourt (NCI)
”The peritoneal tissue resident macrophage niche is dynamic and is supported by both stromal and circulating immune cells”
Speed Talk 3: Tomoaki Yoshida (NIDDK)
“Wild-derived Skin Microbiota Drive Eosinophil Levels in Multiple Organs via IL-5 Produced by Dermal ILC2s”
RRBITC cafeteria, downtown restaurants, food trucks
1:00pm-2:00pm Even number presenters
2:00pm-3:00pm Odd number presenters
*2:30pm-3:00pm - refreshments available
Chairs: Nihal Altan-Bonnet (NHLBI) & Oyebola Oyesola (NIAID)
Talk 1: Vasileios Ionas Theofilou (NIDCR)
“Spatial atlas of human oral mucosa reveals an immune- activated epithelium actively recruiting neutrophils to police the barrier”
Talk 2: Dan Corral (NIAID)
“Mammary intra-epithelial lymphocytes promote lactogenesis and offspring fitness”
Speed Talk 1: Hiroshi Ichise (NIAID)
“Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung”
Speed Talk 2: Grozdan Cvijetic (NIDCR)
“Myeloid Notch2 deficiency results in altered intestinal barrier immunity and dysbiosis”
Speed Talk 3: Lunhua Liu (FDA)
“Milk dictates neonatal serum mediated macrophage phenotype and function in suckling neonates”
Chairs: Romina Goldszmid (NCI) & Peter Kim (NCI)
Talk 1: Ji Hoon Oh (NIDDK)
“Virtual Memory T cells are Induced by Wild-Derived Microbiota in an IL-15-dependent Manner and Enhance the Response to Immune Checkpoint Inhibitor Therapy”
Speed Talk 1: Jack Bibby (NHLBI)
"Prostate epithelial cell intrinsic C3 represses MYC-driven tumorigenesis"
Speed Talk 2: Abir Panda (NIAID)
“Global inhibition of HLA/LILR interactions by anti-MHC-I augments anti-tumor immunity”
Introduction: Naomi Taylor (NCI)
“Integrating T cell signals: Lessons from Genetics and T cell Biology”
Naomi Taylor (NCI)