Platinum Highlight

A New Molecular Platform for Authentic Transmitted/Founder Viruses

Brandon Keele and his team.

In the past, nonhuman primate research has relied on only a few infectious molecular clones for numerous diverse research projects including pathogenesis, preclinical vaccine evaluations, transmissions, and host vs. pathogen interactions. But new data suggests that there is a selected phenotype of the simian immunodeficiency virus (SIV) that causes infection.


Study Illuminates K-Ras4B Activation, Which May Help Predict Drug Resistance

Hyunbum Jang, Ph.D., and Ruth Nussinov, Ph.D.

Until recently, researchers studying RAS, a family of proteins involved in transmitting signals within cells, believed that the exchange of guanosine 5’-diphosphate (GDP) by guanosine triphosphate (GTP) was sufficient to activate the protein. Once activated, RAS can cause unintended and overactive signaling in cells, which can lead to cell division and, ultimately, cancer.


HIV-1 Viral RNA Dynamics at the Plasma Membrane May Provide Insight into Viral Assembly

Wei-Shau Hu, Ph.D., with co-authors  Olga Nikolaitchik, Ph.D., and Jianbo Chen

Many aspects of how infectious viruses assemble in cells have yet to be completely deciphered. However, as reported in a recent Journal of Virology paper, researchers may be one step closer to understanding how HIV-1, the virus that causes AIDS, assembles and replicates.



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