New Animal Model Could Boost Research on AIDS Drugs and Vaccines

Monkeys with cells illustration
Wednesday, June 25, 2014

By Frank Blanchard, Staff Writer, and Jeff Lifson, Guest Writer

In a research milestone reported in the June 20 issue of the journal Science, scientists have developed a minimally modified version of HIV-1, the virus that causes AIDS in infected humans, that is capable of causing progressive infection and AIDS in monkeys. The advance should help create more authentic animal models of the disease and provide a potentially invaluable approach for faster and better preclinical evaluation of new drugs and vaccines.

Tags:

New Hires at the National Cancer Institute at Frederick

NCI, Leidos and DMS logos.
Wednesday, June 25, 2014

Fifty-six people joined the facility in January, February, and March 2014.

The National Cancer Institute welcomes…

Shailesh Ambre • Lucia Babini • Hideaki Bando • Sandip Basu • Konstantinos Dimas • Amber Elia • Lan Jin • Yifei Li • Hanhan Liu • Hugo Martinez • Manasi Mayekar • Michele Newton • Sheikh Rahman • Luis Rodriguez • Eric Sterner • Emmanuel Tavares • Yanping Wang • Sarah Watters

Tags:

NCI Researchers Discover Exceptionally Potent Antibodies with Potential for Prophylaxis and Therapy of MERS-Coronavirus Infections

Crystal structures.
Tuesday, June 17, 2014

By Andrea Frydl, Contributing Writer

In a recent article published in the Journal of Virology, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Laboratory of Experimental Immunology (LEI), Cancer and Inflammation Program, NCI Center for Cancer Research, reported the identification of three human monoclonal antibodies (m336, m337, and m338) that target the part of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) that is responsible for binding to its receptor. These antibodies are exceptionally potent inhibitors of MERS-CoV infection and also provide a basis for creating a future MERS-CoV vaccine.

Tags:

How You Can Help Save a Life

Man donating blood.
Wednesday, June 11, 2014

By Carolynne Keenan, Contributing Writer

Kevin Zecher, a maintenance mechanic in Facilities Maintenance and Engineering, Leidos Biomedical Research, Inc., hasn’t missed a double-red cell donation at a blood drive at NCI at Frederick in four years.

He marks the time by his first granddaughter’s birth—that’s when he first decided to donate more than whole blood.

Tags:

Susan Koogle Marks 40+ Years at NCI at Frederick

Studio portrait of Susan Koogle
Tuesday, June 3, 2014

By Nancy Parrish, Staff Writer

In 1973, Susan Koogle commuted from Washington County to a small data processing company in Arlington, Va. When gas prices spiked from 25 to 54 cents a gallon, she began to look for a job closer to home. That’s when she came to work at NCI at Frederick, and in December 2013, she marked her 40th year with the facility.

Tags:

Pages