The Clinical Services Program within the Applied/Developmental Research Directorate maintains a Clinical Support Laboratorythat has expertise covering a broad spectrum of immunologic testing and clinical trial support. Program support can begin at the early stages of clinical trial development to aid in developing a comprehensive strategy for sample collection, processing, and testing with a special emphasis on immunologic testing. The laboratory collaborates with partners to develop customized assays or transfer existing assay technology with assay validation, data analysis and interpretation of results. Examples include:
Multiplex cytokine and biomarker analysis in different matrices of serum, plasma, urine (& saliva) to use in trial monitoring.
Using bioassays to evaluate and confirm cytokine activity
Routine and customized assays of lymphocyte functional activity including proliferation, ELISPOT, and various cytotoxicity assays like ADCC and NK- (&CTL-) mediated target cell killing.
Establishing customized flow cytometry panels for clinical trial monitoring