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Overview

MHL/PHL Website: https://ncifrederick.cancer.gov/Lasp/Mhl/Default.aspx

The Molecular Histopathology Laboratory, MPL (formerly PHL) provides comprehensive research pathology support for animal health monitoring, biomarker discovery/validation, drug development, genomics, and proteomics for NIH and other government scientists on a cost recovered basis.  MHL is organized as multiple process groups that contain cross-trained experts in animal study design, phenotyping of genetically engineered mice (GEM), immunopathology, anatomic pathology, toxicological pathology, and specimen classification/selection for tissue microarray (TMA) construction or laser micro dissection (LCM).  Service offerings include support for rodent necropsy, non-human hematology and clinical chemistry, fixed and frozen tissue embedding; microtomy, histological staining, pathology interpretation and reporting; and molecular pathology including enzyme stains, immunohistochemistry (IHC), RNAscope® in situ hybridization (ISH), and “goal appropriate” target enrichment workflows from frozen/fixed animal and human tissues, paraffin and OCT tissue blocks, and slides including DNA, RNA, and protein yield and quality assessment.  The PHL also offer a range of digital imaging options including gross photography and bright-field or fluorescent digital whole-slide imaging (WSI) suitable for publications, presentations, and grant submissions. Associated Leica Aperio eSlide Manager and Indica Labs HALO Link™ databases facilitate digital slide conferencing as well as advanced digital image analysis and quantification including machine learning.   

Blanket/annual budget request. Because the MHL is a high-volume core that processes 4,000+ work submissions from 300+ submitting groups annually, it utilizes an option within the NAS request submission process that changes the level of review and approval from individual work requests to an annual budget. This eliminates the need to submit a new NAS request for every new sample submission. 

IMPORTANT NOTE: NCI Requesters seeking supplemental funding via the NCI-F Office of the Director Research Support (ODRS) Program, CCR, or CCR Office of Scientific Technology Research (OSTR) may not request this via an annual blanket budget request.  Rather, please submit a separate “ad hoc” NAS request as these follow a separate, scope-specific, approval process.

To establish an annual blanket budget request:   

Select the blue BEGIN REQUEST Link located at the top right and follow the prompts.

Select the Pathology/Histotechnolgy Laboratory as the service area (REQUIRED).

Enter a brief summary of the required scope of work (REQUIRED).  Drop and drag support files.

Check the Box, Yes this is a blanket Request.  

Enter a Custom Reference ID (OPTIONAL) 

Enter a Project Name or Study ID (REQUIRED).  This free text field will help groups with more than one PID keep track of separate funding sources.

Enter the Project Authorized Users (REQUIRED).  This required field allows the PI to specify/list the staff that are authorized to submit work to the PHL on this account.  Standard practice is to require every submitter have a unique account with documented authorization which facilitates reporting of work request by the various members of the lab group (e.g. different post doctoral fellows).

Enter Financial Information, the NCI-F project ID (OPTIONAL).

Enter the FY MHL Annual Budget in US currency $$ (OPTIONAL).  Contact PHL staff for help with this. Alternately visit the MHL Portal where records from past project submissions including cost summaries are available 24/7.  https://ncifrederick.cancer.gov/Lasp/Mhl/Portal/FindRequest.aspx

Enter the Funding Expiry date (MM/DD/YEAR).  Approved budgets automatically expire annually. It is however possible to set an earlier expiry to accommodate severable funding or the internal policies/financial practices of different NIH Institutes.  Cancelation of an ongoing blanket PO is also possible provided work is not currently pending completion/billing. 

Enter Additional Comments.

Complete the Request Submission.  MHL staff will review the scope estimate and then return any revision to the budget for your approval.  Once you confirm, the annual budget request will be routed through required fiscal and scope reviews resulting in a NAS approval number that must be included with each sample submission.  If you have any questions, please call the MHL administrative office 301 846 1281.

 


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