Need help? Email the Webmaster
The function of the Small Animal Imaging Program (SAIP) is to collaborate with NCI investigators in the development of: mouse models, new molecular imaging probes for early detection and therapy, monitor tumors in vivo, and perform drug efficacy studies utilizing in vivo imaging techniques. In addition, the SAIP collaborates with the NCI Center for Strategic Scientific Initiatives (CSSI) Nanotechnology Characterization Laboratory (NCL) to analyze nanoplatforms as part of the cascade assay and assist the NCI/Division of Cancer Treatment and Diagnoses (DCTD) initiatives in developing standards in small animal imaging, integrate imaging into drug development, and develop partnerships with industry for technology and drug development.
An overview and comparison of the SAIP "In Vivo" imaging modalities are listed below (Table 1).
|Modality||Image Resolution (μm)||Image Depth (mm)||3D capability (Tomography)||Probe Sensitivity (mol/L)||Dynamic Studies||Scanner|
|X-Ray CT||5||*||Yes||N/A||No||See nuclear scanners|
|MRI||50||*||Yes||10-3 to 10-5||Yes||Philips 3T|
|Nuclear: PET||1400||*||Yes||10-11 to 10-12||Yes||Siemens Inveon PET/CT|
|Nuclear: SPECT||500 - 2000||*||Yes||10-10 to 10-11||Difficult||Bioscan NanoSPECT/CT|
|Ultrasound||30||Dependent on Transducer||Limited|
(not well characterized)
|Yes||VisualSonics 2100 (Phased Array)|
|10-15 to 10-17||Limited||Xenogen Spectrum|
|Optical: Fluorescence||>1000||Dependent on Fluorophore wavelength||Limited|
|10-9 to 10-12||No||CRi Maestro|
The following validation errors have occurred: