Govind Kunduri, Ph.D., watched as a bright light illuminated a transparent tube full of mutant fruit flies. Then, as he prepared to collect data, something unexpected occurred: the flies began having seizures. The flies’ surprising behavior seemed epileptic, but Kunduri, a postdoctoral fellow in the Cancer and Developmental Biology Laboratory (CDBL), part of the Center for Cancer Research at NCI at Frederick, hadn’t intended to study epilepsy.

Dennis Klinman, M.D., Ph.D., says science is like the surface of a sphere—there are thousands of possible connections between different points. It is fitting, therefore, that on the eve of his retirement, the senior investigator has helped a young scientist connect with her passion.

Ben Orsburn, Ph.D., stood in the middle of a 180-square-foot laboratory, speaking over the white noise that flooded the room. The source of the din—large, desk-sized objects called mass spectrometers—filled nearby rows of lab benches. Orsburn pointed to one along the periphery of the room, a white-and-black box with the words “Orbitrap Fusion” emblazoned on the front in small blue text.

An anti-leukemia compound identified at NCI at Frederick is one step closer to entering clinical trials in humans thanks to a $4.2-million grant from the Cancer Prevention and Research Institute of Texas (CPRIT). CPRIT recently gave the funds to Allterum Therapeutics, Inc., a Texas-based biotechnology startup company created to manufacture the compound, Allterum, and advance it to human trials. The grant represents the first step in the multi-million-dollar process to bring Allterum to the clinic.

Serguei Kozlov, Ph.D., doesn’t recall if it was he who first contacted clinician Udo Rudloff, M.D., Ph.D., or Rudloff who contacted him. He just knows that their resulting two-year collaboration, which recently moved a first-in-class drug for metastatic cancer toward clinical trials, is one of the best he’s ever had.