Draft Paper Overview

Below please find the overview draft papers for each working group. To download the paper, please click on the links:

ABOUT THE MEETING

This meeting is focused on four working group (WG) presentations of five documents aimed at moving the chronic GVHD field fundamentally forward while capitalizing on the achievements of the 2005 and 2014 consensus conferences. Sessions are designed to allow ample time for the discussion and live questions from the participants. Sessions will be recorded and available on the conference website for 30 days after the meeting.

Methods: Each working group was created to encourage global engagement in the topic. Groups worked individually to review the relevant literature and create the initial draft of the paper, which was reviewed and commented on by the Steering Committee. Two iterative rounds of comments from the Steering Committee were collected prior to the November 2020 Consensus Conference with appropriate manuscript revisions. Based on additional comments from independent external reviewers, conference participants and a 30-day post-conference public comment period, the papers will be further revised for the submission.

PROJECT STEERING COMMITTEE MEMBERS

Chairs: Steven Pavletic, M.D., M.S., National Cancer Institute; Stephanie Lee, M.D., M.P.H., Fred Hutchinson Cancer Research Center; Kirk Schultz, M.D., University of British Columbia; Daniel Wolff, M.D., University of Regensburg

Members: Hildegard Greinix, M.D., University of Graz; Sophie Paczesny, M.D., University of South Carolina; Bruce Blazar, M.D., University of Minnesota; Stefanie Sarantopoulos, M.D., Ph.D., Duke University; Joseph Pidala, M.D., Ph.D., Moffitt Cancer Center; Corey Cutler, M.D., M.P.H., FRCPC, Dana Farber Cancer Institute; Gerard Socie, M,D., Ph.D., St-Louis Hospital, Paris; Paul Martin, M.D., Fred Hutchinson Cancer Research Center; Meredith Cowden, M.A., LPCC-S, Cowden Foundation.

PROJECT MANAGEMENT GROUP

Julia Lam, NCI; Dariele Marshall, NCI; Romi Sawhney, NCI and Filip Pirsl, NCI.

ETIOLOGY AND PREVENTION WORKING GROUP 1

Co-Chairs: Stefanie Sarantopoulos, M.D., Ph.D., Duke University and Gerard Socie, M.D., Ph.D., St-Louis Hospital.

Members: Mukta Arora, M.D., M.S., University of Minnesota; Iskra Pusic, M.D., Washington University School of Medicine; Yoshi (Yoshihiro) Inamoto, M.D., National Cancer Institute-Japan; Leo (Leonido) Luznik, M.D., Johns Hopkins University; Pavan Reddy, M.D., University of Michigan; Jerome Ritz, M.D., Dana-Farber Cancer Institute; Betty Hamilton, M.D., Cleveland Clinic; Kirsten Williams, M.D., Emory School of Medicine; Annie Im, M.D., University of Pittsburgh Medical College; John Koreth, M.D., Ph.D., Dana-Farber Cancer Institute; Paul Carpenter, BSc., MBBS., Fred Hutchinson Cancer Research Center; Jacki (Jacqueline)Mays, DDS., MHSc., Ph.D., NIH National Institute of Dental and Craniofacial Research.

EARLY DIAGNOSIS AND PREEMPTION WORKING GROUP 2

Co-Chairs: Corey Cutler, M.D., MPH, FRCPC, Dana Farber Cancer Institute and Joseph Pidala, M.D., Ph.D, Moffit Cancer Center.

Members: Francis Ayuk, M.D., University Medical Center Hamburg; Joseph Pidala, M.D., Ph.D., Moffitt Cancer Center; Helene Schoemans, M.D., University of Leuven; Fiona Dignan BSc, Med Sci, MBChB, FRCP, FRCPath, M.D., Manchester Royal Infirmary; Eric Tkaczyk, M.D., Ph.D., FAAD, Vanderbilt University; Mary Flowers, M.D., Fred Hutchinson Cancer Research Center; Shernan Holtan, M.D., University Minnesota; Carrie Kitko, M.D., Vanderbilt University; Nosha Farhadfar, M.D., University of Florida; Geoff Cuvelier, M.D., FRCPC, Cancer Center Manitoba; Geoffrey Hill, M.D., FRACP, FRCPA, Fred Hutchinson Cancer Research Center; Anita Lawitschka, M.D., Ph.D., Medizinische Universitat Wien.

Contributors: John Levine, M.D. Mount Sinai Hospital; Paul Carpenter BSc., MBBS, Fred Hutchinson Cancer Research Center; Joycelyn Palmer. Ph.D., City of Hope; Tim Randolph, Ph.D., Fred Hutchinson Cancer Research Center.

Ophthalmology: Sandeep Jain, M.D., University of Illinois; Philipp Steven, M.D., University of Cologne; Zhonghui Lou, M.D., Ph.D., Massachusetts General Hospital; Yoko Ogawa, M.D., Ph.D., Keio University School of Medicine; Michael Stern, Ph.D., Purdue Biological Sciences Committee.

Pulmonary: Gregory Yanik, M.D., University of Michigan; Guang-Shing Cheng, M.D., Fred Hutchinson Cancer Research Center.

Dermatology: Edward Cowen, M.D., M.H.Sc., National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH

TREATMENT OF CHRONIC GVHD WORKING GROUP 3

Co-Chairs: Bruce Blazar, M.D., University of Minnesota; Hildegard Greinix, M.D., University of Graz

Members: Daniel Couriel, M.D., M.S., University of Utah; Amin Alousi, M.D., MD Anderson Cancer Center; Vijaya Bhatt, M.D., University of Nebraska; Nataliya Buxbaum, National Cancer Institute, Center for Cancer Research; Kelli Macdonald, Ph.D., Berghofer Research Institute; Robert Zeiser, M.D., University Medical Center Freiburg; Jörg P. Halter, M.D., Universitätsspital Basel; Attilio Olivieri, M.D., Universita Politecnica delle Marche; Alex (Aleksandr) Lazaryan, M.D., MPH, Ph.D., Moffitt Cancer Center; Zachariah DeFilip, M.D., Massachusetts General Hospital; Drazen Pulanic, M.D., Ph.D., University of Zagreb; Ted Gooley, Ph.D., Fred Hutchinson Cancer Research Center; Lori Henderson, Ph.D., NCI Program Officer; Donna Prezepiorka, M.D., Ph.D., US Food and Drug Administration; Geoffrey Hill, M.D., FRACP, FRCPA, Fred Hutchinson Cancer Research Center.

MORBID FORMS OF CHRONIC GVHD WORKING GROUP 4

Co-Chairs: Daniel Wolff, M.D., University of Regensburg; Sophie Paczesny, M.D., University of South Carolina

Members: Jamie Todd, M.D., Duke University; Guang-Shing Cheng, M.D., Fred Hutch; Ajay Sheshadri, M.D., M.S., MDACC; Resat Cinar, Pharm., Ph.D., MBA, NIH; Vedran Radojcic, M.D., University of Utah; Robert Lafyatis, M.D., University of Pittsburgh; Bianca Santomasso, M.D., Ph.D., MSKCC; Ervina Bilic, M.D., Ph.D., University of Zagreb; Sandeep Jain, M.D., University Illinois; Takanori Teshima, M.D., Ph.D., Hokkaido University; Olaf Penack, M.D., Ph.D., Charite Berlin; David Jacobsohn, M.D., ScM, Children's National.

Contributors: Guang-Shing Cheng, M.D., Fred Hutchinson Cancer Research Center; Philipp Steven, M.D., University of Cologne, Yoko Ogawa, M.D., Ph.D., Keio University School of Medicine; Donna Przepiorka, M.D., Ph.D., US Food and Drug Administration; Linda M. Griffith, M.D., MHS, Ph.D., NIH, National Institute of Allergy and Infectious Disease; Kelli MacDonald, Ph.D., Berghofer Research Institute; Robert Zeiser, M.D., University Hospital Freiburg; Vijaya Bhatt, M.D., University of Nebraska Medical Center; W. Taylor Kimberly, M.D., Ph.D., Massachusetts General Hospital; Klemens Angstwurm; Geoffrey D. E. Cuvelier, M.D., FRCPC, Cancer Care Manitoba; E. Holler; Edward W. Cowen, M.D., M.H.Sc, NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases; Kirsten Williams, M.D., Emory University; Anne Bergeron, M.D., Ph.D., St-Louis Hospital; Sarah Anand, M.D., University of Michigan; Shannon R McCurdy, M.D., University of Pennsylvania; Robery Jenq, M.D., MD Anderson Cancer Center; Eneida R. Nemecek, M.D., M.S., MBA, Oregon Health & Science University; Daniel Saban, Ph.D., Duke University; Iago Pinal Fernandez, M.D., Ph.D., NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases.

INDUSTRY SUMMIT

Co-Chairs: Corey Cutler, M.D., MPH, FRCPC, Dana Farber Cancer Institute and Daniel Couriel, M.D., M.S., University of Utah.

ADVOCACY SUMMIT

Co-Chairs: Meredith Cowden, M.A., LPCC-S., Cowden Foundation and Daniel Wolff, M.D., University of Regensburg.

Members: Michelle Bishop, Ph.D., Coping with Cancer & Caregiving, LLC.; Guy Bouguet, France Lymphome Espoir; Peggy Burkhard, NbmtLink; Chiara DeBiase,M.S., Anthony Nolan ; Christina Ferraro, CNP, Cleveland Clinic; Steven Pavletic, M.D., M.S., NCI; Naomi Pineda, BC Children’s Hospital; Helene Schoemans, M.D., University of Leuven; Katie Schoeppner, MSW, LICSW, National Marrow Donor Program; Kirk Schultz, M.D., University of British Columbia; Susan Stewart, BMT InfoNet.

ASTCT-NIH-EBMT JOINT CHRONIC GVHD EDUCATION COMMITTEE

Co-Chairs: Steven Pavletic, M.D., M.S., NCI and Navneet Majhail, MBBS, M.D., M.S., Cleveland Clinic.

Members: Kirk Schultz, M.D., University of British Columbia; Paul Carpenter, BSc, MBBS, Fred Hutchinson Cancer Research Center; Syed Abutalib, M.D, Cancer Treatment Centers of America; Olaf Penack, M.D., Swedish Medical Center; Kyra Newman, MSW, American Society for Transplantation and Cellular Therapy.

INTERNATIONAL ASPECTS

Nada Hamad, BSc, MSc Forensic, MBBS, FRACP, FRCPA, SpeCetClinRes (oncology), BMTSANZ President and Mahmoud Aljurf, M.D., MPH., King Faisal Hospital Riyadh.

ACKNOWLEDGEMENTS

Funding of this project is made possible through the support by the Intramural Program of the National Cancer Institute – Center for Cancer Research. Additional gratitude goes to colleagues form the NIH Intramural and Extramural Research Program institutes and centers. Acknowledgement goes also to the Meredith Cowden GVHD foundation for long lasting and dedicated partnering on this project. Thanks go to all working group participants, independent reviewers, professional societies, advocacy groups, government agencies and to all stakeholders in the hematopoietic stem cell transplantation field in the US and internationally for the generous donation of their work, time, talents and expertise.

For post-conference comments and questions please email to:

CGVHD2020@mail.nih.gov