A Paradox and Alan Rein: Distinguished Retrovirologist Retires from the HIV DRP

Antibody domains are emerging as promising biopharmaceuticals because of their relatively small size compared to full-sized antibodies, which are too large to effectively penetrate tumors and bind to sterically restricted therapeutic targets. In an article published in The Journal of Biological Chemistry, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, reported their design of a novel antibody domain, monomeric CH3 (mCH3).

The Scientific Library’s 14th Annual Book and Media Swap, held on April 16 in the lobby of Building 549, proved to be a popular event. When the swap was rescheduled from fall 2013 to spring 2014, the library staff was uncertain if the response would be equal to previous years, said Sue Wilson, principal manager of the Scientific Library. NCI at Frederick employees rose to the challenge, however, with 87 people donating more than 3,200 books and DVDs, according to Pam Noble, serials technician and book swap team leader.

Summer months carry the threat of severe storms and tornados in our area. Take a few moments to consider how well you are prepared in the event of a tornado warning. The time to prepare for a tornado is before it happens. The Federal Emergency Management Agency (FEMA) provides information on how to prepare and what to do in the event of a tornado.

In a research milestone reported in the June 20 issue of the journal Science, scientists have developed a minimally modified version of HIV-1, the virus that causes AIDS in infected humans, that is capable of causing progressive infection and AIDS in monkeys. The advance should help create more authentic animal models of the disease and provide a potentially invaluable approach for faster and better preclinical evaluation of new drugs and vaccines.

Fifty-six people joined the facility in January, February, and March 2014.