At first, Meredith Yeager, Ph.D., thought there was a mistake in the data. She was examining the association between exposure to ionizing radiation after the 1986 Chernobyl power plant disaster and the frequency of exposed Ukrainians later passing radiation-driven genetic mutations to their children. Previous studies suggested that the children’s DNA should have contained multiple such mutations. It didn’t.

The Spring Research Festival came to Fort Detrick this year without its signature massive tent, the home of a sprawling equipment expo with dozens of booths. It came without audiences in auditoriums or gatherings around scientific posters. The community didn’t circulate between buildings for events. On the surface, it may have seemed that the festival didn’t come at all. But after being cancelled last year due to the pandemic, the annual two-day event did indeed return in a virtual format.

The past year for Ligia Pinto, Ph.D., and her staff has been full of pressure and remote meetings at all hours of the day and night. It’s also been one of partnerships and progress. Pinto heads the Vaccine, Immunity, and Cancer Directorate, the group at the Frederick National Laboratory that’s leading the national SARS-CoV-2 Serological Sciences Network (SeroNet). At this time last year, her laboratories, which specialized in human papillomavirus, antibody science, and serology, had just been asked to help the Food and Drug Administration evaluate the quality of the new SARS-CoV-2 antibody tests that were flooding the market.

Researchers have found a potential therapeutic target for lung squamous cell carcinoma (LSCC), the second most prevalent type of lung cancer. This may pave the way for a targeted therapy for LSCC, which currently has no approved targeted therapies.

Used successfully in several industries, digital twins have the potential to forge a path toward advances in cancer care and research. Frederick National Laboratory is a lead organization in the strategic interagency collaboration between the National Cancer Institute and the U.S. Department of Energy and has been instrumental in the development of innovative technologies for creating a cancer patient digital twin.