For 2023, the National Institutes of Health held its first in-person NIH Research Festival in Bethesda, Maryland, since the start of the pandemic. The five-day event was well attended and included lectures, workshops, posters, and biotech vendor information booths spread across several areas of the campus. While there was a plethora of events, several scientists agreed that the standout features of this year’s festival were the interactions.

With 100 online attendees, 180 in-person participants, 15 posters, 16 technologies, and 45 speakers, the 2023 Technology Showcase offered a whirlwind look into biotechnology innovation happening at the Frederick National Laboratory for Cancer Research and National Cancer Institute.

After three years of COVID-19, science has learned much about the disease and the virus that causes it, SARS-CoV-2. But in the bigger biological and clinical picture, there are still many unanswered questions, says Ligia Pinto, Ph.D. That’s what keeps her group, the Vaccine, Immunity, and Cancer Directorate at Frederick National Laboratory, working hard to hunt down answers.

NCI-MATCH aimed to determine whether certain cancer therapies could be used more broadly. If a medicine is effective against one type of cancer with a specific mutation, the trial asked, could it treat other cancers with the same mutation? After the eight-year trial, scientists say an answer is coming into view.

Early in the COVID-19 pandemic, before vaccines were available and while SARS-CoV-2 was wreaking havoc worldwide, Barry O’Keefe, Ph.D., and longtime collaborators in Brazil and Spain pooled their knowledge and resources to study cyanovirin-N (CV-N), a protein from cyanobacteria, photosynthetic bacteria commonly known as blue-green algae. O’Keefe had a hunch it could be developed to fight the spread of SARS-CoV-2.