Science

Novel Vaccine Approach Achieves “Functional Cure” of AIDS Virus in Monkeys

Jeff Lifson, Brandon Keele, Jacob Estes, and Michael Piatak

From left: Jeff Lifson, M.D., director of the AIDS and Cancer Virus Program; Brandon Keele, Ph.D., head, Viral Evolution Core; Jacob Estes, Ph.D., head, Tissue Analysis Core; and Michael Piatak, Jr., Ph.D., head, Quantitative Molecular Diagnostics Core. This group collaborated with scientists at the Oregon Health & Science University to advance the line of research culminating in the Nature publication describing a novel vaccine approach that achieved a function cure of the AIDS virus in monkeys

By Frank Blanchard, Staff Writer, and Jeff Lifson, Guest Writer

Scientists at the Oregon Health & Science University and the AIDS and Cancer Virus Program of the Frederick National Laboratory for Cancer Research have used a novel vaccine approach to achieve a “functional cure” and apparent eradication of infection with a monkey version of the AIDS virus.

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New Approach for Producing and Purifying IL-15 Heterodimers That Have Potent Immune Effect

Elena Chertova and Cristina Bergamaschi

From left: Elena Chertova, Ph.D., head, Retroviral Protein Chemistry Core, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, and Cristina Bergamaschi, Ph.D., staff scientist, Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research

Platinum Highlight IconBy Nancy Parrish, Staff Writer

Cytokines are proteins that play a crucial role in the human immune system by delivering messages that trigger the activation of immune cells to fight off attacks from viruses or other invaders.

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Spring Research Festival Sponsored by NICBR for First Time

A group of three men.

Left to right: Maryland State Senator Ron Young; Col. Bernard L. DeKoning, then commander, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID); and Craig W. Reynolds, Ph.D., director, Office of Scientific Operations, National Cancer Institute at Frederick.

By Melissa Porter, Staff Writer

For the past 16 years, the annual Spring Research Festival has been sponsored by NCI at Frederick and Fort Detrick to acquaint fellow researchers, students, and the community at large with the important discoveries being made at this facility to fight cancer, AIDS, and other infectious diseases.

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Morrison Receives NIH Award for Major Ras/Raf Breakthroughs

Portrait of Debbie Morrison.

Deborah Morrison, Ph.D., Laboratory Chief, Laboratory of Cell and Developmental Signaling, Center for Cancer Research

By Ashley DeVine, Staff Writer

Deborah Morrison, Ph.D., laboratory chief, Laboratory of Cell and Developmental Signaling, Center for Cancer Research (CCR), received an NIH Director’s Award in June “for major breakthroughs in elucidating the mechanisms of Ras/Raf signaling that will be critical for diagnosis and treatment of disease,” according to the NIH Director’s Awards Ceremony brochure.

She was nominated by Ira Daar, Ph.D., senior investigator, Developmental Signal Transduction Section, Laboratory of Cell and Developmental Signaling, CCR.

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